## Design the time-to-event study in 3 steps

**Endpoints**. Essential information relative to the outcomes**Correlation**. Relationship between endpoints.**Power**. Define the error probabilities to perform sample size calculations**Follow-up**. Define the study times

**Summary**. A brief report of general results.**Sample size**. Total sample size needed for different scenarios.**Effect size**. Hazard Ratio over time.**Endpoint selection**. Choice about considering the use of a composite endpoint.

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**interpretation boxes**Effect size

Sample size